1453082-52-4
1453082-52-4
Chemical Structure
NVP-CLR457
- CAS No.: 1453082-52-4
- Formula:C18H20F3N7O4
- Molecular Weight:455.39
IUPAC Name: (4S,5R)-3-(2'-amino-2-morpholino-4'-(trifluoromethyl)-[4,5'-bipyrimidin]-6-yl)-4-(hydroxymethyl)-5-methyloxazolidin-2-one
InChIKey: IEYOHYVYEJVEJJ-SKDRFNHKSA-N
SMILES: NC1=NC(C(F)(F)F)=C(C2=NC(N3CCOCC3)=NC(N4[C@H]([C@H](OC4=O)C)CO)=C2)C=N1
Biological Activity: NVP-CLR457 (compound 40) is an orally active, potent and balanced pan-class I PI3K inhibitor. NVP-CLR457 shows a clear dose-dependent PK/PD/efficacy relationship. NVP-CLR457 has antitumor activity[1].
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NVP-CLR457 | NVP-CLR457 (compound 40) is an orally active, potent and balanced pan-class I PI3K inhibitor. NVP-CLR457 shows a clear dose-dependent PK/PD/efficacy relationship. NVP-CLR457 has antitumor activity. | |||||||||||||||||||||
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