1456509-46-8
Chemical Structure
Trimebutine 3-TCBS
Synonym(s): GIC-1001
- CAS No.: 1456509-46-8
- Formula:C29H36N2O8S2
- Molecular Weight:604.73
IUPAC Name: 2-(dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate 3-carbamothioylbenzenesulfonate
InChIKey: ACKBGPXURGPUEW-UHFFFAOYSA-N
SMILES: O=C(C1=CC(OC)=C(C(OC)=C1)OC)OCC(N(C)C)(CC)C2=CC=CC=C2.O=S(C3=CC=CC(C(N)=S)=C3)(O)=O
Biological Activity: Trimebutine 3-TCBS (GIC-1001) is an innovative formulation designed to release hydrogen sulfide (H2S) in vivo. This compound combines trimebutine with an H2S-releasing antagonist (phenyl 3-thiocarbamate) and exhibits enhanced anti-nociceptive effects in a mouse colonic distension model, superior to conventional trimebutine. GIC-1001 can reduce visceral pain and discomfort associated with lumen distension in a dose-dependent manner, showing potential superiority[1].
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Trimebutine 3-TCBS | 98.0% | Trimebutine 3-TCBS (GIC-1001) is an innovative formulation designed to release hydrogen sulfide (H2S) in vivo. This compound combines trimebutine with an H2S-releasing antagonist (phenyl 3-thiocarbamate) and exhibits enhanced anti-nociceptive effects in a mouse colonic distension model, superior to conventional trimebutine. GIC-1001 can reduce visceral pain and discomfort associated with lumen distension in a dose-dependent manner, showing potential superiority. | ||||||||||||||||||||
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