1457983-33-3
1457983-33-3
Chemical Structure
Denfivontinib hydrochloride
Synonym(s): G-749 hydrochloride
- CAS No.: 1457983-33-3
- Formula:C25H26BrClN6O2
- Molecular Weight:557.87
IUPAC Name: 8-bromo-2-((1-methylpiperidin-4-yl)amino)-4-((4-phenoxyphenyl)amino)pyrido[4,3-d]pyrimidin-5(6H)-one hydrochloride
InChIKey: UDYYCTJUUMIMHX-UHFFFAOYSA-N
SMILES: O=C1NC=C(C2=C1C(NC3=CC=C(C=C3)OC4=CC=CC=C4)=NC(NC5CCN(CC5)C)=N2)Br.Cl
Biological Activity: Denfivontinib (G-749) hydrochloride is an AXL inhibitor that has synergistic antitumor effects with the PD-1 inhibitor Pembrolizumab (HY-P9902). Denfivontinib can enhance the NOD-like receptor pathway, thereby promoting the formation of the NLRP3 inflammasome[1].
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Denfivontinib hydrochloride | Denfivontinib (G-749) hydrochloride is an AXL inhibitor that has synergistic antitumor effects with the PD-1 inhibitor Pembrolizumab (HY-P9902). Denfivontinib can enhance the NOD-like receptor pathway, thereby promoting the formation of the NLRP3 inflammasome. | |||||||||||||||||||||
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