145819-92-7
Chemical Structure
Emtricitabine triphosphate
Synonym(s): (-)-Emtricitabine triphosphate
- CAS No.: 145819-92-7
- Formula:C8H13FN3O12P3S
- Molecular Weight:487.19
IUPAC Name: ((2R,5S)-5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl tetrahydrogen triphosphate
InChIKey: WIEOLFZNMKSGEX-NTSWFWBYSA-N
SMILES: O=P(O)(OP(O)(OP(O)(O)=O)=O)OC[C@@H]1O[C@H](N2C=C(F)C(N)=NC2=O)CS1
Biological Activity: Emtricitabine triphosphate ((-)-Emtricitabine triphosphate) is the phosphorylated active metabolite of Emtricitabine (HY-17427). Emtricitabine triphosphate inhibits HIV-1 reverse transcriptase and incorporates into the nascent viral DNA chain, causing chain termination. Emtricitabine triphosphate can serve as a biomarker for assessing adherence to antiretroviral therapy. Emtricitabine triphosphate (tetrasodium salt) can be used in research related to HIV infection[1].
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Emtricitabine triphosphate | Emtricitabine triphosphate ((-)-Emtricitabine triphosphate) is the phosphorylated active metabolite of Emtricitabine (HY-17427). Emtricitabine triphosphate inhibits HIV-1 reverse transcriptase and incorporates into the nascent viral DNA chain, causing chain termination. Emtricitabine triphosphate can serve as a biomarker for assessing adherence to antiretroviral therapy. Emtricitabine triphosphate (tetrasodium salt) can be used in research related to HIV infection. | |||||||||||||||||||||
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