145969-30-8
145969-30-8
Chemical Structure
OPC-14523 free base
- CAS No.: 145969-30-8
- Formula:C23H28ClN3O2
- Molecular Weight:413.94
IUPAC Name: 1-(3-(4-(3-chlorophenyl)piperazin-1-yl)propyl)-5-methoxy-3,4-dihydroquinolin-2(1H)-one
InChIKey: TZZGTNZBLPCBIS-UHFFFAOYSA-N
SMILES: O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)C4=C(C(OC)=CC=C4)CC1
Biological Activity: OPC-14523 free base is an orally active sigma and 5-HT1A receptor agonist, with high affinity for sigma receptors (σ1/2 IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 nM), and the 5-HT transporter (IC50=80 nM). OPC-14523 free base shows antidepressant-like activity[1][2].
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OPC-14523 free base | OPC-14523 free base is an orally active sigma and 5-HT1A receptor agonist, with high affinity for sigma receptors (σ1/2 IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 nM), and the 5-HT transporter (IC50=80 nM). OPC-14523 free base shows antidepressant-like activity. | |||||||||||||||||||||
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References
- [1]. Tottori K, et al. Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523. Neuropharmacology. 2001;41(8):976-988. [Content Brief]
- [2]. Bermack JE, et al. Effects of the potential antidepressant OPC-14523 [1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone monomethanesulfonate] a combined sigma and 5-HT1A ligand: modulation of neuronal activity in the dorsal raphe nucleus. J Pharmacol Exp Ther. 2004;310(2):578-583. [Content Brief]
