1459695-66-9
Chemical Structure
TXA6101
- CAS No.: 1459695-66-9
- Formula:C18H10BrF5N2O3
- Molecular Weight:477.18
IUPAC Name: 3-((5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)methoxy)-2,6-difluorobenzamide
InChIKey: ONGPJYSSZQHFBU-UHFFFAOYSA-N
SMILES: O=C(N)C1=C(F)C=CC(OCC2=NC(C3=CC=C(C(F)(F)F)C=C3)=C(Br)O2)=C1F
Biological Activity: TXA6101 is a bacterial protein FtsZ (filamentous temperature-sensitive protein Z) inhibitor that inhibits bacterial division. TXA6101 has antimicrobial activity against MRSA isolates expressing either the G193D or G196S mutant FtsZ with the MIC value of 1 μg/mL, retains significant activity against the TXA707-resistant FtsZ mutant. TXA6101 can be used as a potential method against Gram-negative bacterial infections[1][2].
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TXA6101 | TXA6101 is a bacterial protein FtsZ (filamentous temperature-sensitive protein Z) inhibitor that inhibits bacterial division. TXA6101 has antimicrobial activity against MRSA isolates expressing either the G193D or G196S mutant FtsZ with the MIC value of 1 μg/mL, retains significant activity against the TXA707-resistant FtsZ mutant. TXA6101 can be used as a potential method against Gram-negative bacterial infections. | |||||||||||||||||||||
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References
- [1]. Andrea Casiraghi, et al. Targeting Bacterial Cell Division: A Binding Site-Centered Approach to the Most Promising Inhibitors of the Essential Protein FtsZ. Antibiotics (Basel). 2020 Feb 7;9(2):69. [Content Brief]
- [2]. Junso Fujita, et al. Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ. ACS Chem Biol. 2017 Jul 21;12(7):1947-1955. [Content Brief]
