1469988-63-3
Chemical Structure
QL-X-138
- CAS No.: 1469988-63-3
- Formula:C25H19N5O2
- Molecular Weight:421.45
IUPAC Name: N-(2-methyl-5-(2-oxo-9-(1H-pyrazol-4-yl)benzo[h][1,6]naphthyridin-1(2H)-yl)phenyl)acrylamide
InChIKey: JMVDIGHUQAXWIE-UHFFFAOYSA-N
SMILES: C=CC(NC1=CC(N2C(C=CC3=C2C4=CC(C5=CNN=C5)=CC=C4N=C3)=O)=CC=C1C)=O
Biological Activity: QL-X-138 is a potent and selective BTK/MNK dual kinase inhibitor, exhibits covalent binding to BTK and non-covalent binding to MNK. QL-X-138 shows IC50s of 9.4 nM, 107.4 nM and 26 nM for BTK, MNK1 and MNK2 kinases respectively. QL-X-138 also shows anti-dengue virus 2 activity, with an IC50 of 3.5 μM. QL-X-138 can be used for the research of B-cell malignancies[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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QL-X-138 | 98.17% | QL-X-138 is a potent and selective BTK/MNK dual kinase inhibitor, exhibits covalent binding to BTK and non-covalent binding to MNK. QL-X-138 shows IC50s of 9.4 nM, 107.4 nM and 26 nM for BTK, MNK1 and MNK2 kinases respectively. QL-X-138 also shows anti-dengue virus 2 activity, with an IC50 of 3.5 μM. QL-X-138 can be used for the research of B-cell malignancies. | ||||||||||||||||||||
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