1471479-22-7
Chemical Structure
TLD-1433
- CAS No.: 1471479-22-7
- Formula:C49H38Cl2N8RuS3
- Molecular Weight:1007.05
InChIKey: AVOZSOCUVHJHTQ-UHFFFAOYSA-L
SMILES: CC1=CC=[N](C2=C1)[Ru+2]([N]3=CC=C4)([N](C5=C6)=CC=C6C)([N](C5=C7)=CC=C7C)([N](C2=C8)=CC=C8C)[N]9=CC=CC%10=C9C3=C4C%11=C%10NC(C%12=CC=C(C%13=CC=C(C%14=CC=CS%14)S%13)S%12)=N%11.[Cl-].[Cl-]
Biological Activity: TLD-1433 is a ruthenium (II)-based water-soluble photodynamic compound. TLD-1433 inactivates enveloped viruses by inducing lipid peroxidation. TLD-1433 inactivates a variety of human pathogenic enveloped and non-enveloped viruses. TLD-1433 can be used in the research of viral infections and BCG-unresponsive non-muscle invasive bladder cancer[1][2].
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TLD-1433 | TLD-1433 is a ruthenium (II)-based water-soluble photodynamic compound. TLD-1433 inactivates enveloped viruses by inducing lipid peroxidation. TLD-1433 inactivates a variety of human pathogenic enveloped and non-enveloped viruses. TLD-1433 can be used in the research of viral infections and BCG-unresponsive non-muscle invasive bladder cancer. | |||||||||||||||||||||
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References
- [1]. Coombs KM, et al. Nanomolar concentrations of the photodynamic compound TLD-1433 effectively inactivate numerous human pathogenic viruses. Heliyon. 2024 Jun 15;10(11):e32140. [Content Brief]
- [2]. Kulkarni GS, et al. A Phase 1b Clinical Study of Intravesical Photodynamic Therapy in Patients with Bacillus Calmette-Guérin-unresponsive Non-muscle-invasive Bladder Cancer. Eur Urol Open Sci. 2022 Jun 1;41:105-111.
