147388-83-8
147388-83-8
Chemical Structure
ABT-418 hydrochloride
- CAS No.: 147388-83-8
- Formula:C9H15ClN2O
- Molecular Weight:202.68
IUPAC Name: (S)-3-methyl-5-(1-methylpyrrolidin-2-yl)isoxazole hydrochloride
InChIKey: VOXHERKWAIEJQF-QRPNPIFTSA-N
SMILES: CN1[C@H](C2=CC(C)=NO2)CCC1.Cl
Biological Activity: ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ABT-418 hydrochloride | 99.37% | ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease. | ||||||||||||||||||||
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ABT-418 hydrochloride (Standard) | ≥98% | ABT-418 hydrochloride (Standard) is the analytical standard of ABT-418 hydrochloride (HY-105170B). This product is intended for research and analytical applications. ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease. | ||||||||||||||||||||
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Epiboxidine | Epiboxidine is a potent and selective neural nAChR agonist with Kis of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs, respectively. Epiboxidine is a methylisoxazole analog of the alkaloid Epibatidine, and is also an analog of another nAChR agonist, ABT 418. | |||||||||||||||||||||
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Epiboxidine hydrochloride | Epiboxidine hydrochloride is a potent and selective neural nAChR agonist with Kis of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs, respectively. Epiboxidine hydrochloride is a methylisoxazole analog of the alkaloid Epibatidine, and is also an analog of another nAChR agonist, ABT 418. | |||||||||||||||||||||
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ABT-418 | ABT-418 is a selective neuronal nicotinic acetylcholine receptor ligand with activity in improving spatial memory. ABT-418 administered before training can significantly reduce the spatial discrimination deficit caused by ventricular damage. ABT-418 is considered to be a potential treatment for attention deficit disorder. | |||||||||||||||||||||
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Altinicline | Altinicline (SIB-1508Y free base) is a selective α4β2 nicotinic acetylcholine receptor (nAChR) agonist, with no activity against α7 or α1β1γδ nAChRs and only extremely low activity against α3β4 nAChRs. Altinicline reverses escape deficits and increases avoidance responses. Altinicline is applicable to research related to depression. | |||||||||||||||||||||
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(S)-6-Methylnicotine | 98.0% | (S)-6-Methylnicotine is a nicotinic acetylcholine receptor (nAChR) agonist that exhibits agonistic activity on isolated guinea pig ileum. (S)-6-Methylnicotine produces sensations identical to those of nicotine and has addictive potential. (S)-6-Methylnicotine shows high cytotoxicity against human bronchial epithelial cells and exerts a weak effect on the upregulation of lung cancer-related proteins. (S)-6-Methylnicotine can be used in the research of respiratory system diseases. | ||||||||||||||||||||
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3-Hydroxymethyl-5-methylisoxazole | 3-Hydroxymethyl-5-methylisoxazole (5-Methylisoxazole-3-methanol) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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(S)-N-Methylpyrrolidine-2-methanol | 99.91% | (S)-N-Methylpyrrolidine-2-methanol is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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5-Methylisoxazol-3-amine | 99.70% | 5-Methylisoxazol-3-amine (5-Methyl-1,2-oxazol-3-amine) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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(2'S)-Nicotine 1-oxide | (2'S)-Nicotine 1-oxide ((2S)-Nicotine 1-N-oxide) is an alkaloid N-oxide, which is found in leaves, stems and roots of Nicotiana tabacum. | |||||||||||||||||||||
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α-Nicotine | α-Nicotine is the α-isomer of Nicotine. Nicotine is a nicotinic acetylcholine receptor (nAChR) agonist. Nicotine is promising for research of neuropsychiatric disorders (e.g., schizophrenia, ADHD). | |||||||||||||||||||||
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References
- [1]. Brioni JD, et al. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418. J Pharmacol Exp Ther. 1994 Oct;271(1):353-61. [Content Brief]
- [2]. Guo T, et al. A comparative study of the effects of ABT-418 and methylphenidate on spatial memory in an animal model of ADHD. Neurosci Lett. 2012 Oct 18;528(1):11-5. [Content Brief]
