147529-30-4
Chemical Structure
β-Amyloid (1-9)
- CAS No.: 147529-30-4
- Formula:C42H60N14O17
- Molecular Weight:1033.01
IUPAC Name: (5S,8S,11S,14S,17S,20S,23S,26S)-11-((1H-imidazol-4-yl)methyl)-26-amino-17-benzyl-20-(2-carboxyethyl)-8-(carboxymethyl)-14-(3-guanidinopropyl)-5-(hydroxymethyl)-23-methyl-4,7,10,13,16,19,22,25-octaoxo-3,6,9,12,15,18,21,24-octaazaoctacosanedioic acid
InChIKey: BRRKPUCEVBBGNV-WVQSQKPFSA-N
SMILES: O=C(O)CNC([C@H](CO)NC([C@H](CC(O)=O)NC([C@H](CC1=CNC=N1)NC([C@H](CCCNC(N)=N)NC([C@H](CC2=CC=CC=C2)NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@H](CC(O)=O)N)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: β-Amyloid (1-9), an N-terminal fragment of beta amyloid, consists of amino acid residues 1 to 9. β-Amyloid (1-9) contains a B cell epitope, but it does not include T cell epitopes. Omission of residues 1 to 9 from the full-length Alzheimer'sβ-Amyloid peptide 1 to 40 does not prevent the peptide from forming amyloid fibrils or eliminate fibril polymorphism [1][2].
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β-Amyloid (1-9) | β-Amyloid (1-9), an N-terminal fragment of beta amyloid, consists of amino acid residues 1 to 9. β-Amyloid (1-9) contains a B cell epitope, but it does not include T cell epitopes. Omission of residues 1 to 9 from the full-length Alzheimer'sβ-Amyloid peptide 1 to 40 does not prevent the peptide from forming amyloid fibrils or eliminate fibril polymorphism . | |||||||||||||||||||||
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References
- [1]. Zamora E, et al. Papillomavirus-like particles are an effective platform for amyloid-beta immunization in rabbitsand transgenic mice. J Immunol. 2006 Aug 15;177(4):2662-2670. [Content Brief]
- [2]. Paravastu AK, et al. Polymorphic fibril formation by residues 10-40 of the Alzheimer's beta-amyloid peptide. Biophys J. 2006 Jun 15;90(12):4618-29. [Content Brief]
