147663-04-5
147663-04-5
Chemical Structure
7-Hydroxyrisperidone
Synonym(s): 7-RispOH
- CAS No.: 147663-04-5
- Formula:C23H27FN4O3
- Molecular Weight:426.48
IUPAC Name: 3-(2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-7-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
InChIKey: ABWPQNZPAOAQSG-UHFFFAOYSA-N
SMILES: O=C1C(CCN2CCC(CC2)C3=NOC4=C3C=CC(F)=C4)=C(C)N=C5N1CC(CC5)O
Biological Activity: 7-Hydroxyrisperidone (7-RispOH) is a metabolite of Risperidone (HY-11018). Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist[1][2].
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7-Hydroxyrisperidone | 7-Hydroxyrisperidone (7-RispOH) is a metabolite of Risperidone (HY-11018). Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist. | |||||||||||||||||||||
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References
- [1]. Liana I de Jesus, et al. Enantioselective fungal biotransformation of risperidone in liquid culture medium by capillary electrophoresis and hollow fiber liquid-phase microextraction. Electrophoresis. 2011 Oct;32(19):2765-75. [Content Brief]
- [2]. Nyberg S, et al. 5-HT2 and D2 dopamine receptor occupancy in the living human brain. A PET study with risperidone. Psychopharmacology (Berl). 1993;110(3):265-72. [Content Brief]
