148093-65-6
Chemical Structure
Defensin HNP-1 human
- CAS No.: 148093-65-6
- Formula:C150H222N44O38S6
- Molecular Weight:3442.03
SMILES: O=C([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@](NC([C@@]1([H])NC([C@](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@](NC([C@]2([H])CSSC[C@](C(N[C@@H](CSSC[C@@H](C(N[C@H](C(N[C@](CSSC1)([H])C(N[C@H](C(N[C@@](C(N3[C@](CCC3)([H])C(N[C@H](C(N2)=O)C)=O)=O)([H])[C@@H](C)CC)=O)CCCNC(N)=N)=O)=O)CC4=CC=C(C=C4)O)=O)NC([C@@H](N)C)=O)C(O)=O)=O)([H])NC([C@@H](NC([C@@H](NC5=O)C)=O)CC6=CC=CC=C6)=O)=O)([H])[C@@H](C)CC)=O)C)=O)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC7=CC=C(C=C7)O)=O)=O)([H])[C@H](O)C)=O)=O)([H])[C@@H](C)CC)=O)CC8=CC=C(C=C8)O)=O)CCC(N)=O)=O)=O)CCCNC(N)=N)=O)CC(C)C)N[C@H]5CC9=CNC%10=CC=CC=C9%10
Biological Activity: Defensin HNP-1 human is a type of human neutrophil peptide (HNPs). Defensin HNP-1 human possesses immunomodulatory functions and can delay the apoptosis of neutrophils. Defensin HNP-1 human inhibits DNA/RNA/protein synthesis and interferes with metabolic pathways, thus exhibiting broad antibacterial activity. Defensin HNP-1 human has direct inactivation effects on HIV, HSV-1, HSV-2, CMV, influenza virus, etc. Defensin HNP-1 human has antileishmanial activity. Defensin HNP-1 human is involved in endothelial cell dysfunction during the early development of atherosclerosis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Defensin HNP-1 human | 98.12% | Defensin HNP-1 human is a type of human neutrophil peptide (HNPs). Defensin HNP-1 human possesses immunomodulatory functions and can delay the apoptosis of neutrophils. Defensin HNP-1 human inhibits DNA/RNA/protein synthesis and interferes with metabolic pathways, thus exhibiting broad antibacterial activity. Defensin HNP-1 human has direct inactivation effects on HIV, HSV-1, HSV-2, CMV, influenza virus, etc. Defensin HNP-1 human has antileishmanial activity. Defensin HNP-1 human is involved in endothelial cell dysfunction during the early development of atherosclerosis. | ||||||||||||||||||||
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References
- [1]. Dabirian S, et, al. Human neutrophil peptide-1 (HNP-1): a new anti-leishmanial drug candidate. PLoS Negl Trop Dis. 2013 Oct 17;7(10):e2491. [Content Brief]
- [2]. Higazi M, et, al. Opposing effects of HNP1 (α-defensin-1) on plasma cholesterol and atherogenesis. PLoS One. 2020 Apr 17;15(4):e0231582. [Content Brief]
- [3]. Zhang J, et al. HNP-1: From Structure to Application Thanks to Multifaceted Functions. Microorganisms. 2025 Feb 19;13(2):458. [Content Brief]
