148550-96-3
Chemical Structure
PD 144795
- CAS No.: 148550-96-3
- Formula:C13H15NO4S
- Molecular Weight:281.33
IUPAC Name: 3-isopropoxy-5-methoxycinnamamide 1-oxide
InChIKey: VCBBOEAKKOXRTJ-UHFFFAOYSA-N
SMILES: O=C(N)C1=C(OC(C)C)C=2C=C(OC)C=CC2S1=O
Biological Activity: PD 144795 is an orally active inhibitor of E-selectin (E-selectin), ICAM-1, and VCAM-1, with IC50 values of 6.6 μM, 4.0-10 μM, and 4.0 μM for the human targets, respectively. PD 144795 has favorable pharmacokinetic properties, including good absorption and no endothelial cytotoxicity. PD 144795 inhibits TNF-α-induced adhesion of neutrophils and monocytes to endothelial cells, reduces neutrophil infiltration, exudate accumulation, and footpad swelling, and delays disease progression in rodent models. PD 144795 can be used for inflammation-related research[1].
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PD 144795 | PD 144795 is an orally active inhibitor of E-selectin (E-selectin), ICAM-1, and VCAM-1, with IC50 values of 6.6 μM, 4.0-10 μM, and 4.0 μM for the human targets, respectively. PD 144795 has favorable pharmacokinetic properties, including good absorption and no endothelial cytotoxicity. PD 144795 inhibits TNF-α-induced adhesion of neutrophils and monocytes to endothelial cells, reduces neutrophil infiltration, exudate accumulation, and footpad swelling, and delays disease progression in rodent models. PD 144795 can be used for inflammation-related research. | |||||||||||||||||||||
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