148642-42-6
Chemical Structure
GR127935 hydrochloride
- CAS No.: 148642-42-6
- Formula:C29H32ClN5O3
- Molecular Weight:534.05
IUPAC Name: N-(4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride
InChIKey: SRVVUYIJVBLEJI-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C2=CC=C(C3=NOC(C)=N3)C=C2C)C=C1)NC4=CC=C(OC)C(N5CCN(C)CC5)=C4.[H]Cl
Biological Activity: GR127935 hydrochloride is a selective and orally active 5-HT1D and 5-HT1B receptor antagonist with pKi values of 8.5 for both receptors. GR127935 hydrochloride impairs memory acquisition and Serotonin (HY-B1473A)-mediated vasodilation. GR127935 hydrochloride can be used for research on amnesia, neuroendocrine cancer, and migraine[1][2][3].
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GR127935 hydrochloride | 99.38% | GR127935 hydrochloride is a selective and orally active 5-HT1D and 5-HT1B receptor antagonist with pKi values of 8.5 for both receptors. GR127935 hydrochloride impairs memory acquisition and Serotonin (HY-B1473A)-mediated vasodilation. GR127935 hydrochloride can be used for research on amnesia, neuroendocrine cancer, and migraine. | ||||||||||||||||||||
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References
- [1]. Nasehi M, et al. Possible involvement of CA1 5-HT1B/1D and 5-HT2A/2B/2C receptors in harmaline-induced amnesia. Pharmacol Biochem Behav. 2014 Oct;125:70-77. [Content Brief]
- [2]. Choi YD, et al. Altered vasomotor function and endothelial impairment in a neuroendocrine tumor mouse model. American journal of surgery. 2026 Jul;257:116938.
- [3]. J W Clitherow, et al. Evolution of a novel series of [(N,N-dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists. J Med Chem. 1994 Jul 22;37(15):2253-7. [Content Brief]
