1487423-58-4
Chemical Structure
Floramanoside F
- CAS No.: 1487423-58-4
- Formula:C23H22O14
- Molecular Weight:522.41
InChIKey: IGQMRYUGGMTLIC-KCEXQJOMSA-N
SMILES: O=C(C(O)=C(C1=CC(O)=C(C=C1)O)O2)C(C2=C3O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)C(OCC)=O)=C(C=C3O)O
Biological Activity: Floramanoside F is a type of flavonol glycoside compound. Floramanoside F has a moderate free radical scavenging effect, with a SC₅₀ value of 25.1 μM. Floramanoside F has a relatively weak inhibitory activity on aldose reductase, with a IC₅₀ value greater than 100 μM. Floramanoside F has strong binding affinity with key target enzymes of type 1 diabetic nephropathy (T1DN) (Fasn, Cyp2e1, Cyp4a32), and can inhibit lipid accumulation and oxidative stress, thereby alleviating renal inflammation and fibrosis. Floramanoside F can be used to study type 1 diabetic nephropathy and diabetic complications[1][2].
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Floramanoside F | Floramanoside F is a type of flavonol glycoside compound. Floramanoside F has a moderate free radical scavenging effect, with a SC₅₀ value of 25.1 μM. Floramanoside F has a relatively weak inhibitory activity on aldose reductase, with a IC₅₀ value greater than 100 μM. Floramanoside F has strong binding affinity with key target enzymes of type 1 diabetic nephropathy (T1DN) (Fasn, Cyp2e1, Cyp4a32), and can inhibit lipid accumulation and oxidative stress, thereby alleviating renal inflammation and fibrosis. Floramanoside F can be used to study type 1 diabetic nephropathy and diabetic complications. | |||||||||||||||||||||
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References
- [1]. Yan X, et al. Exploring the molecular mechanisms for renoprotective effects of Huangkui capsule on diabetic nephropathy mice by comprehensive serum metabolomics analysis. J Ethnopharmacol. 2025;340:119223. [Content Brief]
- [2]. Zhang Y, et al. Antioxidative flavonol glycosides from the flowers of Abelmouschus manihot. J Nat Med. 2013;67(1):78-85. [Content Brief]
