148796-53-6
148796-53-6
Chemical Structure
alpha-Hydroxy farnesyl phosphonic acid
Synonym(s): Hydroxyfarnesyl phosphate
- CAS No.: 148796-53-6
- Formula:C15H27O4P
- Molecular Weight:302.35
IUPAC Name: ((2E,6E)-1-hydroxy-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)phosphonic acid
InChIKey: MONZTFSZTWQCKH-IJFRVEDASA-N
SMILES: C/C(C)=C\CC/C(C)=C/CC/C(C)=C/C(P(O)(O)=O)O
Biological Activity: α-hydroxy Farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl transferase (FTase). At concentrations greater than 1 μM, α-hydroxy farnesyl phosphonic acid inhibits the processing of Ras in Ha-ras-transformed NIH3T3 cells.
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alpha-Hydroxy farnesyl phosphonic acid | α-hydroxy Farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl transferase (FTase). At concentrations greater than 1 μM, α-hydroxy farnesyl phosphonic acid inhibits the processing of Ras in Ha-ras-transformed NIH3T3 cells. | |||||||||||||||||||||
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