1489263-00-4
1489263-00-4
Chemical Structure
KI-7
- CAS No.: 1489263-00-4
- Formula:C23H18N2O2
- Molecular Weight:354.40
IUPAC Name: 2-(1-benzyl-1H-indol-3-yl)-2-oxo-N-phenylacetamide
InChIKey: MQMGZFRIEZRHHJ-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC=C1)C(C2=CN(CC3=CC=CC=C3)C4=C2C=CC=C4)=O
Biological Activity: KI-7 is an A2B adenosine receptor positive allosteric modulator. KI-7 potentiates the cAMP accumulation induced by the non-selective A2B adenosine receptor agonist NECA (EC50=445.8 nM). KI-7 also potentiates the cAMP accumulation induced by the selective A2B adenosine receptor agonist BAY 60-6583 as well as by adenosine with EC50s of 2390 nM and 2550 nM, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KI-7 | 99.16% | KI-7 is an A2B adenosine receptor positive allosteric modulator. KI-7 potentiates the cAMP accumulation induced by the non-selective A2B adenosine receptor agonist NECA (EC50=445.8 nM). KI-7 also potentiates the cAMP accumulation induced by the selective A2B adenosine receptor agonist BAY 60-6583 as well as by adenosine with EC50s of 2390 nM and 2550 nM, respectively. | ||||||||||||||||||||
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References
- [1]. Trincavelli ML, et al. Allosteric modulators of human A2B adenosine receptor. Biochim Biophys Acta. 2014;1840(3):1194-1203. [Content Brief]
- [2]. Trincavelli ML, et al. Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators. Biochim Biophys Acta. 2014;1843(12):2957-2966. [Content Brief]
