149286-90-8
Chemical Structure
(Z)-RG-13022
Synonym(s): (Z)-Tyrphostin RG13022
- CAS No.: 149286-90-8
- Formula:C16H14N2O2
- Molecular Weight:266.29
IUPAC Name: (Z)-3-(3,4-dimethoxyphenyl)-2-(pyridin-3-yl)acrylonitrile
InChIKey: DBGZNJVTHYFQJI-RIYZIHGNSA-N
SMILES: N#C/C(C1=CN=CC=C1)=C\C2=CC(OC)=C(C=C2)OC
Biological Activity: (Z)-RG-13022 is a tyrosine kinase (TK) inhibitor, which inhibits preferentially the TK activity of the EGF receptor and inhibits EGF-stimulated growth of cultured cells. (Z)-RG-13022 exerts an IC50 of 11 μM for DNA synthesis in the HN5 cells, which is 3 times more potent than (E)-RG-13022 (IC50=38 μM). (Z)-RG-13022 can be used for research of breast cancer cells[1][2].
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(Z)-RG-13022 | (Z)-RG-13022 is a tyrosine kinase (TK) inhibitor, which inhibits preferentially the TK activity of the EGF receptor and inhibits EGF-stimulated growth of cultured cells. (Z)-RG-13022 exerts an IC50 of 11 μM for DNA synthesis in the HN5 cells, which is 3 times more potent than (E)-RG-13022 (IC50=38 μM). (Z)-RG-13022 can be used for research of breast cancer cells. | |||||||||||||||||||||
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References
- [1]. Reddy KB, et al. Inhibition of breast cancer cell growth in vitro by a tyrosine kinase inhibitor. Cancer Res. 1992 Jul 1;52(13):3636-41. [Content Brief]
- [2]. McLeod HL, et al. In vivo pharmacology and anti-tumour evaluation of the tyrphostin tyrosine kinase inhibitor RG13022. Br J Cancer. 1996 Dec;74(11):1714-8. [Content Brief]
