1496553-39-9
Chemical Structure
SMA-12b
- CAS No.: 1496553-39-9
- Formula:C13H22INO2S
- Molecular Weight:383.29
IUPAC Name: N,N,N-trimethyl-2-((4-methylbenzyl)sulfonyl)ethan-1-aminium iodide
InChIKey: HWCJFPAHNSHXPO-UHFFFAOYSA-M
SMILES: O=S(CC[N+](C)(C)C)(CC1=CC=C(C=C1)C)=O.[I-]
Biological Activity: SMA-12b is a small molecule analogue of the parasitic worm compound ES-62. SMA-12b has immunomodulatory activity, acting by regulating the expression of multiple inflammatory response genes, especially those associated with inflammatory bodies. SMA-12b significantly reduces the expression of cytokine IL-1β associated with inflammatory bodies and inhibites the production of IL-1β through a mechanism mediated by NRF2. SMA-12b can be used in the study of rheumatoid arthritis (RA) and other autoimmune diseases[1].
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SMA-12b | SMA-12b is a small molecule analogue of the parasitic worm compound ES-62. SMA-12b has immunomodulatory activity, acting by regulating the expression of multiple inflammatory response genes, especially those associated with inflammatory bodies. SMA-12b significantly reduces the expression of cytokine IL-1β associated with inflammatory bodies and inhibites the production of IL-1β through a mechanism mediated by NRF2. SMA-12b can be used in the study of rheumatoid arthritis (RA) and other autoimmune diseases. | |||||||||||||||||||||
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