149820-74-6
149820-74-6
Chemical Structure
Xemilofiban
- CAS No.: 149820-74-6
- Formula:C18H22N4O4
- Molecular Weight:358.39
IUPAC Name: ethyl (S)-3-(4-((4-carbamimidoylphenyl)amino)-4-oxobutanamido)pent-4-ynoate
InChIKey: ZHCINJQZDFCSEL-CYBMUJFWSA-N
SMILES: C#C[C@@H](NC(CCC(NC1=CC=C(C=C1)C(N)=N)=O)=O)CC(OCC)=O
Biological Activity: Xemilofiban is an orally active glycoprotein IIb/IIIa blocking agent. Xemilofiban inhibits platelet aggregation. Xemilofiban reduces the incidence of thrombosis[1][2].
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Xemilofiban | Xemilofiban is an orally active glycoprotein IIb/IIIa blocking agent. Xemilofiban inhibits platelet aggregation. Xemilofiban reduces the incidence of thrombosis. | |||||||||||||||||||||
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References
- [1]. Kereiakes DJ, et al. Pharmacodynamic efficacy, clinical safety, and outcomes after prolonged platelet Glycoprotein IIb/IIIa receptor blockade with oral xemilofiban: results of a multicenter, placebo-controlled, randomized trial. Circulation. 1998 Sep 29;98(13):1268-78. [Content Brief]
- [2]. Frederick LG, et al. Protective effect of oral xemilofiban in arterial thrombosis in dogs: increased activity in combination with aspirin. Circulation. 1998 Aug 25;98(8):813-20. [Content Brief]
