149859-17-6
149859-17-6
Chemical Structure
MDL 101146
- CAS No.: 149859-17-6
- Formula:C29H37F5N4O6
- Molecular Weight:632.62
IUPAC Name: (2S)-1-((4-(morpholine-4-carbonyl)benzoyl)-L-valyl)-N-(5,5,6,6,6-pentafluoro-2-methyl-4-oxohexan-3-yl)pyrrolidine-2-carboxamide
InChIKey: XQAMVCHQGHAELT-NHNZYLEHSA-N
SMILES: O=C(N(CCC1)[C@@H]1C(NC(C(C)C)C(C(F)(F)C(F)(F)F)=O)=O)[C@H](C(C)C)NC(C(C=C2)=CC=C2C(N3CCOCC3)=O)=O
Biological Activity: MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a Ki value of 25 nM. MDL 101146 can be used for the research of arthritis[1][2].
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MDL 101146 | MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a Ki value of 25 nM. MDL 101146 can be used for the research of arthritis. | |||||||||||||||||||||
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References
- [1]. Angelastro M, et al. Inhibition of human neutrophil elastase with peptidyl [Content Brief]
- [2]. M J Janusz, et al. Inhibition of cartilage degradation in rat collagen-induced arthritis but not adjuvant arthritis by the neutrophil elastase inhibitor MDL 101,146. Inflamm Res. 1997 Dec;46(12):503-8. [Content Brief]
