149904-87-0
149904-87-0
Chemical Structure
Darglitazone Sodium
Synonym(s): CP 86325 Sodium
- CAS No.: 149904-87-0
- Formula:C23H19N2NaO4S
- Molecular Weight:442.46
IUPAC Name: sodium 5-(4-(3-(5-methyl-2-phenyloxazol-4-yl)propanoyl)benzyl)-2,4-dioxothiazolidin-3-ide
InChIKey: AMCPCELVARAPHJ-UHFFFAOYSA-M
SMILES: O=C([N-]1)SC(CC2=CC=C(C(CCC3=C(C)OC(C4=CC=CC=C4)=N3)=O)C=C2)C1=O.[Na+]
Biological Activity: Darglitazone Sodium, a thiazolidinedione, is an orally active, potent, and selective PPAR-γ (peroxisome proliferator-activated receptor) agonist. Darglitazone Sodium is effective in controlling blood glucose and lipid metabolism, and can be used for type II diabetes research[1][2].
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Darglitazone Sodium | Darglitazone Sodium, a thiazolidinedione, is an orally active, potent, and selective PPAR-γ (peroxisome proliferator-activated receptor) agonist. Darglitazone Sodium is effective in controlling blood glucose and lipid metabolism, and can be used for type II diabetes research. | |||||||||||||||||||||
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References
- [1]. Rashmi Kumari, et al. The PPAR-gamma agonist, darglitazone, restores acute inflammatory responses to cerebral hypoxia-ischemia in the diabetic ob/ob mouse. J Cereb Blood Flow Metab. 2010 Feb;30(2):352-60. [Content Brief]
- [2]. Hoenig M, Ferguson DC. Effect of darglitazone on glucose clearance and lipid metabolism in obese cats. Am J Vet Res. 2003 Nov;64(11):1409-13. [Content Brief]
