150057-49-1
150057-49-1
Chemical Structure
1954U89
- CAS No.: 150057-49-1
- Formula:C16H21N5
- Molecular Weight:283.37
InChIKey: YBHNZQJIFKDDHM-UHFFFAOYSA-N
SMILES: CC(N1C(CC)CC)=CC2=C1C=CC3=NC(N)=NC(N)=C23
Biological Activity: 1954U89 is a potent, lipid-soluble and orally active inhibitor of dihydrofolate reductase (DHFR). 1954U89 exhibits anticancer activity[1][2].
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1954U89 | 1954U89 is a potent, lipid-soluble and orally active inhibitor of dihydrofolate reductase (DHFR). 1954U89 exhibits anticancer activity. | |||||||||||||||||||||
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References
- [1]. Studenberg SD, et al. The pharmacokinetics of 1954U89, 1,3-diamino-7-(1-ethylpropyl)-8-methyl-7H-pyrrolo-(3,2-f)quinazoline, in dogs and rats after intravenous and oral administration. Biopharm Drug Dispos. 1997 Jul;18(5):433-42. [Content Brief]
- [2]. Chen J C, et al. QSAR Studies on a Series of 7, 8‐Dialkyl‐1, 3‐diaminopyrrolo‐[3, 2‐f] quinazolines with Anticancer Activity[J]. Chinese Journal of Chemistry, 2006, 24(11): 1531-1537.
