150403-96-6
Chemical Structure
Methyl-L-NIO hydrochloride
- CAS No.: 150403-96-6
- Formula:C8H18ClN3O2
- Molecular Weight:223.70
IUPAC Name: (S)-2-amino-5-propionimidamidopentanoic acid hydrochloride
InChIKey: FADRJPGCWHNIBW-RGMNGODLSA-N
SMILES: N[C@@H](CCCNC(CC)=N)C(O)=O.Cl
Biological Activity: Methyl-L-NIO (compound 2d) hydrochloride is a potential selective inhibitor (IC50: 70 μM) of dimethylarginine dimethylaminohydrolase hDDAH. Methyl-L-NIO also has inhibitory activity against NO synthase. The inhibition rates of Methyl-L-NIO on different isoforms of NO synthase at a concentration of 100 μM are 77% (nNOS), 20% (eNOS), and 72% (iNOS) respectively; the inhibition rates at a concentration of 1 mM are 100% (nNOS), 85% (eNOS), 100% (iNOS)[1].
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Methyl-L-NIO hydrochloride | Methyl-L-NIO (compound 2d) hydrochloride is a potential selective inhibitor (IC50: 70 μM) of dimethylarginine dimethylaminohydrolase hDDAH. Methyl-L-NIO also has inhibitory activity against NO synthase. The inhibition rates of Methyl-L-NIO on different isoforms of NO synthase at a concentration of 100 μM are 77% (nNOS), 20% (eNOS), and 72% (iNOS) respectively; the inhibition rates at a concentration of 1 mM are 100% (nNOS), 85% (eNOS), 100% (iNOS). | |||||||||||||||||||||
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