150418-07-8
Chemical Structure
Rp-8-Br-cGMPS
Synonym(s): Rp-8-bromo-Cyclic GMPS
- CAS No.: 150418-07-8
- Formula:C10H11BrN5O6PS
- Molecular Weight:440.17
IUPAC Name: 2-amino-8-bromo-9-((2R,4aR,6R,7R,7aS)-7-hydroxy-2-mercapto-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-3,9-dihydro-6H-purin-6-one
InChIKey: KRYIOQOBMVFLBO-DGCJZISUSA-N
SMILES: O=C1C2=C(N([C@H]3[C@H](O)[C@H](O4)[C@@H](CO[P@]4(S)=O)O3)C(Br)=N2)NC(N)=N1
Biological Activity: Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is a potent Ca2+-ATPase activator. Rp-8-Br-cGMPS is also an agonist of the rod CNG channel and an inhibitor of PKG. Rp-8-Br-cGMPS sodium salt mediates cytosolic Ca2+ reduction by activating Ca2+-ATPase and subsequently removing Ca2+ from the cell[1][2].
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Rp-8-Br-cGMPS | Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is a potent Ca2+-ATPase activator. Rp-8-Br-cGMPS is also an agonist of the rod CNG channel and an inhibitor of PKG. Rp-8-Br-cGMPS sodium salt mediates cytosolic Ca2+ reduction by activating Ca2+-ATPase and subsequently removing Ca2+ from the cell. | |||||||||||||||||||||
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References
- [1]. Rashatwar SS, et, al. Effects of 8-bromo-cGMP on Ca2+ levels in vascular smooth muscle cells: possible regulation of Ca2+-ATPase by cGMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1987 Aug;84(16):5685-9. [Content Brief]
- [2]. Barnstable CJ, et al. Modulation of synaptic function by cGMP and cGMP-gated cation channels. Neurochem Int. 2004 Nov;45(6):875-84. [Content Brief]
