1504558-72-8
1504558-72-8
Chemical Structure
Nec-3a
- CAS No.: 1504558-72-8
- Formula:C21H18F4N2O4
- Molecular Weight:438.37
IUPAC Name: 1-((3S,3aS)-3-(3-fluoro-4-(trifluoromethoxy)phenyl)-8-methoxy-3,3a,4,5-tetrahydro-2H-benzo[g]indazol-2-yl)-2-hydroxyethanone
InChIKey: RPGVJSZQQKMKSB-JLTOFOAXSA-N
SMILES: COC1=CC=C2CC[C@H]3[C@@H](C4=CC=C(C(F)=C4)OC(F)(F)F)N(C(CO)=O)N=C3C2=C1
Biological Activity: Nec-3a is a Necrostatin-3 analogue. Nec-3a is a RIP1 inhibitor (IC50: 0.44 μM). Nec-3a inhibits the autophosphorylation activity of the RIP1 kinase domain[1].
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Nec-3a | Nec-3a is a Necrostatin-3 analogue. Nec-3a is a RIP1 inhibitor (IC50: 0.44 μM). Nec-3a inhibits the autophosphorylation activity of the RIP1 kinase domain. | |||||||||||||||||||||
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