1508339-76-1
1508339-76-1
Chemical Structure
SSR103800
- CAS No.: 1508339-76-1
- Formula:C22H21Cl2F3N2O
- Molecular Weight:457.32
InChIKey: VUBUDJCRCAHMBH-FOIQADDNSA-N
SMILES: O=C(C1=C(C(C(F)(F)F)=CC=C1Cl)Cl)N[C@H](C2=CC=CC=C2)[C@@]3([H])C4CCN(CC4)C3
Biological Activity: SSR103800 is an orally active and selective glycine transporter-1 (GlyT1) inhibitor with an IC50 of 2 nM for hGlyT1. SSR103800 elevates synaptic glycine levels by blocking GlyT1, thereby indirectly enhancing glutamate-NMDA receptor function. SSR103800 can be used for research on schizophrenia and depression[1][2].
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SSR103800 | SSR103800 is an orally active and selective glycine transporter-1 (GlyT1) inhibitor with an IC50 of 2 nM for hGlyT1. SSR103800 elevates synaptic glycine levels by blocking GlyT1, thereby indirectly enhancing glutamate-NMDA receptor function. SSR103800 can be used for research on schizophrenia and depression. | |||||||||||||||||||||
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References
- [1]. Boulay D, et al. Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia. Pharmacology, biochemistry, and behavior. 2008 Nov;91(1):47-58.
- [2]. Boulay D, et al. The glycine transporter-1 inhibitor SSR103800 displays a selective and specific antipsychotic-like profile in normal and transgenic mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2010 Jan;35(2):416-27.
