150973-78-7
150973-78-7
Chemical Structure
Germicidin B
- CAS No.: 150973-78-7
- Formula:C10H14O3
- Molecular Weight:182.22
IUPAC Name: 3-ethyl-4-hydroxy-6-isopropyl-2H-pyran-2-one
InChIKey: SZBDLUWYHDLLAG-UHFFFAOYSA-N
SMILES: O=C1OC(C(C)C)=CC(O)=C1CC
Biological Activity: Germicidin B is an antibiotic with bactericidal activity. Germicidin B inhibits hexokinase II with an IC50 of 25.16 μM. Germicidin B suppresses spore germination in Streptomyces. Germicidin B is applicable to studies on bacterial infections[1][2][3].
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Germicidin B | Germicidin B is an antibiotic with bactericidal activity. Germicidin B inhibits hexokinase II with an IC50 of 25.16 μM. Germicidin B suppresses spore germination in Streptomyces. Germicidin B is applicable to studies on bacterial infections. | |||||||||||||||||||||
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References
- [1]. Aoki Y, Matsumoto D, Kawaide H, Natsume M. Physiological role of germicidins in spore germination and hyphal elongation in Streptomyces coelicolor A3(2). J Antibiot (Tokyo). 2011 Sep;64(9):607-11. [Content Brief]
- [2]. Zhang XM, et al. Hexokinase II Inhibitory Effect of Secondary Metabolites Derived from a Streptomyces sp. Associated with Mud Dauber Wasp. Chem Biodivers. 2020;17(7):e2000140. [Content Brief]
- [3]. Song L, et al. Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. J Am Chem Soc. 2006;128(46):14754-14755. [Content Brief]
