151-41-7
Chemical Structure
Lauryl sulfate
Synonym(s): Dodecyl hydrogen sulphate; Dodecyl sulfate
- CAS No.: 151-41-7
- Formula:C12H26O4S
- Molecular Weight:266.40
IUPAC Name: dodecyl hydrogen sulfate
InChIKey: MOTZDAYCYVMXPC-UHFFFAOYSA-N
SMILES: O=S(=O)(O)OCCCCCCCCCCCC
Biological Activity: Lauryl sulfate (Dodecyl hydrogen sulphate) is an anionic chaotropic surfactant. Lauryl sulfate dissolves viral envelopes, denatures viral proteins, inhibits viral infectivity and HIV-1 syncytium formation. Lauryl sulfate potently inhibits the infectivity of HSV-1 strain F (ED50 = 17.9 μM) and HSV-2 strain 333 (ED50 = 32.7 μM). Lauryl sulfate induces environmental toxicity, disrupting environmental balance and physiological processes of organisms. As a contaminant, Lauryl sulfate is toxic to aquatic and terrestrial organisms. Lauryl sulfate can be used in studies related to sexually transmitted infections[1][2][3][4][5][6].
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Lauryl sulfate | Lauryl sulfate (Dodecyl hydrogen sulphate) is an anionic chaotropic surfactant. Lauryl sulfate dissolves viral envelopes, denatures viral proteins, inhibits viral infectivity and HIV-1 syncytium formation. Lauryl sulfate potently inhibits the infectivity of HSV-1 strain F (ED50 = 17.9 μM) and HSV-2 strain 333 (ED50 = 32.7 μM). Lauryl sulfate induces environmental toxicity, disrupting environmental balance and physiological processes of organisms. As a contaminant, Lauryl sulfate is toxic to aquatic and terrestrial organisms. Lauryl sulfate can be used in studies related to sexually transmitted infections. | |||||||||||||||||||||
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References
- [1]. Nakamura R, et al. Chemical properties of fatty acid derivatives as inhibitors of DNA polymerases. Org Biomol Chem. 2007 Dec 21;5(24):3912-21. [Content Brief]
- [2]. Asio J R G, et al. Sodium lauryl sulfate and its potential impacts on organisms and the environment: A thematic analysis[J]. Emerging Contaminants, 2023, 9(1): 100205.
- [3]. Guo Y, et al. Pharmaceutical Lauryl Sulfate Salts: Prevalence, Formation Rules, and Formulation Implications. Molecular pharmaceutics. 2022 Feb 07;19(2):432-439. [Content Brief]
- [4]. Piret J, et al. Sodium lauryl sulfate, a microbicide effective against enveloped and nonenveloped viruses. Current drug targets. 2002 Feb;3(1):17-30. [Content Brief]
- [5]. Piret J, et al. In vitro and in vivo evaluations of sodium lauryl sulfate and dextran sulfate as microbicides against herpes simplex and human immunodeficiency viruses. Journal of clinical microbiology. 2000 Jan;38(1):110-9. [Content Brief]
- [6]. Leoty-Okombi S, et al. Effect of sodium lauryl sulfate (SLS) applied as a patch on human skin physiology and its microbiota[J]. Cosmetics, 2021, 8(1): 6.
