152-84-1
Chemical Structure
Ruberythric acid
- CAS No.: 152-84-1
- Formula:C25H26O13
- Molecular Weight:534.47
InChIKey: GCGGSVAWTYHZBI-CVQRFVFPSA-N
SMILES: O=C1C2=C(O)C(O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO[C@H]4[C@@H]([C@H]([C@@H](CO4)O)O)O)=CC=C2C(C5=CC=CC=C51)=O
Biological Activity: Ruberythric acid is a natural product found in madder (Rubia tinctorum). Acid treatment induces hydrolysis of Ruberythric acid, producing pentose-containing sugar residues and alizarin. Ruberythric acid inhibits stimulus-induced phosphorylation of IKK, IκBα and p65 in the NF-κB pathway, regulates tight junction integrity, suppresses stimulus-induced MLCK activation and myosin light chain phosphorylation, reduces tight junction disruption associated with cytoskeletal contraction, alleviates stimulus-induced increase in intestinal permeability, and prevents stimulus-induced redistribution of tight junction proteins. Ruberythric acid forms red salts when dissolved in alkali and can be used as a dye. Ruberythric acid is applicable to research related to inflammatory bowel disease[1][2][3].
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Ruberythric acid | Ruberythric acid is a natural product found in madder (Rubia tinctorum). Acid treatment induces hydrolysis of Ruberythric acid, producing pentose-containing sugar residues and alizarin. Ruberythric acid inhibits stimulus-induced phosphorylation of IKK, IκBα and p65 in the NF-κB pathway, regulates tight junction integrity, suppresses stimulus-induced MLCK activation and myosin light chain phosphorylation, reduces tight junction disruption associated with cytoskeletal contraction, alleviates stimulus-induced increase in intestinal permeability, and prevents stimulus-induced redistribution of tight junction proteins. Ruberythric acid forms red salts when dissolved in alkali and can be used as a dye. Ruberythric acid is applicable to research related to inflammatory bowel disease. | |||||||||||||||||||||
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References
- [1]. Jo HJ, et al. Therapeutic Potential of Ruberythric Acid in Intestinal Inflammation and Barrier Function Reduction. Preventive nutrition and food science. 2026 Feb;31(1):pnf.2025.236. [Content Brief]
- [2]. Jones E T. 275. Natural glycosides. Part V. Ruberythric acid. J. Chem. Soc., 1933, 136: 1167‑1169.
- [3]. Wouters J, et al. A Comparative Investigation of Hydrolysis Methods to Analyze Natural Organic Dyes by HPLC‑PDA NINE METHODS, TWELVE BIOLOGICAL SOURCES, TEN DYE CLASSES, DYED YARNS, PIGMENTS AND PAINTS. Studies in Conservation, 2011, 56(3): 231‑249.
