152051-21-3
152051-21-3
Chemical Structure
ELDKWA
- CAS No.: 152051-21-3
- Formula:C35H52N8O11
- Molecular Weight:760.83
InChIKey: ZWZMMYQPAMAECB-OXEZHCTRSA-N
SMILES: OC(CC[C@H](N)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](C)C(O)=O)=O)CC1=CNC2=CC=CC=C12)=O)=O)=O)=O)=O
Biological Activity: ELDKWA is the highly conserved amino acids on the ecto-domain of gp41. ELDKWA acts as the epitope of a neutralizing monoclonal antibody 2F5 (mAb 2F5) directed against human immunodeficiency virus type 1[1][2].
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ELDKWA | ELDKWA is the highly conserved amino acids on the ecto-domain of gp41. ELDKWA acts as the epitope of a neutralizing monoclonal antibody 2F5 (mAb 2F5) directed against human immunodeficiency virus type 1. | |||||||||||||||||||||
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References
- [1]. T Muster, et al. Cross-neutralizing activity against divergent human immunodeficiency virus type 1 isolates induced by the gp41 sequence ELDKWAS. J Virol. 1994 Jun;68(6):4031-4. [Content Brief]
- [2]. Y Tian, et al. Structure-affinity relationships in the gp41 ELDKWA epitope for the HIV-1 neutralizing monoclonal antibody 2F5: effects of side-chain and backbone modifications and conformational constraints. J Pept Res. 2002 Jun;59(6):264-76. [Content Brief]
