152068-09-2
Chemical Structure
YO-PRO-1
- CAS No.: 152068-09-2
- Formula:C24H29I2N3O
- Molecular Weight:629.32
IUPAC Name: (Z)-4-((3-methylbenzo[d]oxazol-2(3H)-ylidene)methyl)-1-(3-(trimethylammonio)propyl)quinolin-1-ium iodide
InChIKey: ULHRKLSNHXXJLO-UHFFFAOYSA-L
SMILES: C[N+](CCC[N+]1=C2C=CC=CC2=C(/C=C3OC4=CC=CC=C4N\3C)C=C1)(C)C.[I-].[I-]
Biological Activity: YO-PRO-1 is a non-cell-membrane-penetrating green fluorescent dye. YO-PRO-1 cannot penetrate normal cell membranes but can penetrate the membranes of apoptotic and necrotic cells. YO-PRO-1 has a high affinity for DNA. When it is not bound to DNA, it emits almost no fluorescence, and when it binds to DNA, it can emit green fluorescence (Ex/Em: 488/530±30 nM). YO-PRO-1 is often used together with Propidium Iodide (HY-D0815) to analyze and identify apoptotic and necrotic cells[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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YO-PRO-1 | 98.2% | YO-PRO-1 is a non-cell-membrane-penetrating green fluorescent dye. YO-PRO-1 cannot penetrate normal cell membranes but can penetrate the membranes of apoptotic and necrotic cells. YO-PRO-1 has a high affinity for DNA. When it is not bound to DNA, it emits almost no fluorescence, and when it binds to DNA, it can emit green fluorescence (Ex/Em: 488/530±30 nM). YO-PRO-1 is often used together with Propidium Iodide (HY-D0815) to analyze and identify apoptotic and necrotic cells. | ||||||||||||||||||||
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References
- [1]. Boffa DJ, et al. Measurement of apoptosis of intact human islets by confocal optical sectioning and stereologic analysis of YO-PRO-1-stained islets. Transplantation. 2005 Apr 15;79(7):842-5. [Content Brief]
- [2]. Fujisawa S, et al. Evaluation of YO-PRO-1 as an early marker of apoptosis following radiofrequency ablation of colon cancer liver metastases. Cytotechnology. 2014 Mar;66(2):259-73. [Content Brief]
