152110-04-8
Chemical Structure
Humilinolide A
- CAS No.: 152110-04-8
- Formula:C31H40O11
- Molecular Weight:588.64
InChIKey: ADDLXGZBTXNVDS-ZCWMACHDSA-N
SMILES: O[C@@]12[C@]3([H])[C@@]4(O3)[C@@](CC[C@@]5([C@@]4([H])CC(O[C@H]5C6=COC=C6)=O)C)([H])[C@@](C1=O)([C@@](C(C)([C@@H]2OC(C(C)C)=O)C)([H])[C@@H](O)C(OC)=O)C
Biological Activity: Humilinolide A is a limonoid compound. Humilinolide A can be isolated from Swietenia humilis. Humilinolide A binds to estrogen-dependent receptors on the plasma membrane of the myometrium, thereby triggering uterine contraction responses. Humilinolide A induces irreversible, concentration-dependent increases in the tension, amplitude and frequency of smooth muscle contraction. Humilinolide A inhibits radicle growth of barnyard grass (Echinochloa crus-galli) with a IC50 of 99.0 µg/mL. Humilinolide A exhibits antifeedant activity. Humilinolide A can be used in studies related to gastrointestinal motility regulation and reproductive smooth muscle function[1][2][3].
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Humilinolide A | Humilinolide A is a limonoid compound. Humilinolide A can be isolated from Swietenia humilis. Humilinolide A binds to estrogen-dependent receptors on the plasma membrane of the myometrium, thereby triggering uterine contraction responses. Humilinolide A induces irreversible, concentration-dependent increases in the tension, amplitude and frequency of smooth muscle contraction. Humilinolide A inhibits radicle growth of barnyard grass (Echinochloa crus-galli) with a IC50 of 99.0 µg/mL. Humilinolide A exhibits antifeedant activity. Humilinolide A can be used in studies related to gastrointestinal motility regulation and reproductive smooth muscle function. | |||||||||||||||||||||
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References
- [1]. Perusquía M, et al. Contractile response induced by a limonoid (humilinolide A) on spontaneous activity of isolated smooth muscle[J]. Phytotherapy Research: An International Journal Devoted to Medical and Scientific Research on Plants and Plant Products, 1997, 11(5): 354-357.
- [2]. Narender T, et al. Occurrence, biosynthesis, biological activity and NMR spectroscopy of D and B, D ring seco-limonoids of Meliaceae family[J]. Natural Product Communications, 2007, 2(2): 1934578X0700200219.
- [3]. Segura-Correa R, et al. New tetranortriterpenoids from Swietenia humilis[J]. Journal of Natural Products, 1993, 56(9): 1567-1574.
