152121-51-2
152121-51-2
Chemical Structure
p38 MAPK-IN-11
- CAS No.: 152121-51-2
- Formula:C20H14FN3
- Molecular Weight:315.35
IUPAC Name: 4-(5-(4-fluorophenyl)-2-phenyl-1H-imidazol-4-yl)pyridine
InChIKey: AZBHFSLUTGHEPH-UHFFFAOYSA-N
SMILES: FC=1C=CC(=CC1)C=2NC(=NC2C=3C=CN=CC3)C=4C=CC=CC4
Biological Activity: p38 MAPK-IN-11 is a CSBP (p38 MAPK) kinase inhibitor with IC50 values of 0.15 μM (binding activity) and 0.21 μM (inhibitory activity). p38 MAPK-IN-11 shows weak inhibitory activity against PKCα kinase, with an IC50 of 7.6 μM. p38 MAPK-IN-11 inhibits the production of IL-1. p38 MAPK-IN-11 also acts as a β-lactam antibiotic potentiator, but has no antibacterial activity itself[1][2].
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p38 MAPK-IN-11 | p38 MAPK-IN-11 is a CSBP (p38 MAPK) kinase inhibitor with IC50 values of 0.15 μM (binding activity) and 0.21 μM (inhibitory activity). p38 MAPK-IN-11 shows weak inhibitory activity against PKCα kinase, with an IC50 of 7.6 μM. p38 MAPK-IN-11 inhibits the production of IL-1. p38 MAPK-IN-11 also acts as a β-lactam antibiotic potentiator, but has no antibacterial activity itself. | |||||||||||||||||||||
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