152243-63-5
Chemical Structure
Keap1-Nrf2-IN-31
- CAS No.: 152243-63-5
- Formula:C27H36O7
- Molecular Weight:472.57
InChIKey: JYKGBLLZZJRIGP-XDXGNBCUSA-N
SMILES: CC(C=C1)=CC2=C1C(C)(C)OC3=C2C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)=CC(CCCCC)=C3
Biological Activity: Keap1-Nrf2-IN-31 is a potent Keap1-Nrf2 interaction (PPI) inhibitor. Keap1-Nrf2-IN-31 binds with dual high affinity to the KDC (Kd = 1.2 μM (MST assay); Kd = 171 nM (SRP assay)) and BTB (Kd = 71 nM (MST assay); Kd = 74.1 nM (SRP assay)) domains of Keap1, inhibits the function of the Keap1-Cul3 complex and blocks the ubiquitination-mediated degradation of Nrf2, thereby promoting Nrf2 nuclear translocation and activating the expression of antioxidant genes. Keap1-Nrf2-IN-31 can be used for research on Parkinson's disease[1].
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Keap1-Nrf2-IN-31 | Keap1-Nrf2-IN-31 is a potent Keap1-Nrf2 interaction (PPI) inhibitor. Keap1-Nrf2-IN-31 binds with dual high affinity to the KDC (Kd = 1.2 μM (MST assay); Kd = 171 nM (SRP assay)) and BTB (Kd = 71 nM (MST assay); Kd = 74.1 nM (SRP assay)) domains of Keap1, inhibits the function of the Keap1-Cul3 complex and blocks the ubiquitination-mediated degradation of Nrf2, thereby promoting Nrf2 nuclear translocation and activating the expression of antioxidant genes. Keap1-Nrf2-IN-31 can be used for research on Parkinson's disease. | |||||||||||||||||||||
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