152273-12-6
Chemical Structure
U93631
- CAS No.: 152273-12-6
- Formula:C17H21N3O2
- Molecular Weight:299.37
IUPAC Name: tert-butyl 4,4-dimethyl-4,5-dihydroimidazo[1,5-a]quinoxaline-3-carboxylate
InChIKey: NXBSEJKZKXIYMD-UHFFFAOYSA-N
SMILES: O=C(C1=C2N(C=N1)C3=C(C=CC=C3)NC2(C)C)OC(C)(C)C
Biological Activity: U93631 is a GABAA receptor inhibitor targeting the picrotoxin (HY-101391) site, which exhibits higher inhibitory potency in receptors lacking α subunits. U93631 blocks GABA-induced chloride currents, exerts a mild initial stimulatory effect on activated currents, but its activity decreases in β2T246F mutant receptors. U93631 can serve as a ligand for the convulsant site of GABAA receptors in relevant studies[1][2].
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U93631 | 99.70% | U93631 is a GABAA receptor inhibitor targeting the picrotoxin (HY-101391) site, which exhibits higher inhibitory potency in receptors lacking α subunits. U93631 blocks GABA-induced chloride currents, exerts a mild initial stimulatory effect on activated currents, but its activity decreases in β2T246F mutant receptors. U93631 can serve as a ligand for the convulsant site of GABAA receptors in relevant studies. | ||||||||||||||||||||
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U93631 (Standard) | ≥98% | U93631 (Standard) is the analytical standard of U93631 (HY-100686). This product is intended for research and analytical applications. 0 | ||||||||||||||||||||
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References
- [1]. Dillon GH, et al. Enhancement by GABA of the association rate of picrotoxin and tert-butylbicyclophosphorothionate to the rat cloned alpha 1 beta 2 gamma 2 GABAA receptor subtype. Br J Pharmacol. 1995 Jun;115(3):539-45. [Content Brief]
- [2]. Bell-Horner CL, et al. Influence of subunit configuration on the interaction of picrotoxin-site ligands with recombinant GABA(A) receptors. Brain Res Mol Brain Res. 2000;76(1):47-55. [Content Brief]
