152302-45-9
152302-45-9
Chemical Structure
7-Desmethyl-agomelatine
- CAS No.: 152302-45-9
- Formula:C14H15NO2
- Molecular Weight:229.28
IUPAC Name: N-(2-(7-hydroxynaphthalen-1-yl)ethyl)acetamide
InChIKey: UNTZQBYXDYYXIY-UHFFFAOYSA-N
SMILES: CC(NCCC1=C2C=C(O)C=CC2=CC=C1)=O
Biological Activity: 7-Desmethyl-agomelatine is a metabolite of Agomelatine. Agomelatineis a potent agonist at melatonin receptors (MT1 and MT2), and also is an antagonist of 5-HT2C[1][2].
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7-Desmethyl-agomelatine | 99.89% | 7-Desmethyl-agomelatine is a metabolite of Agomelatine. Agomelatineis a potent agonist at melatonin receptors (MT1 and MT2), and also is an antagonist of 5-HT2C. | ||||||||||||||||||||
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7-Desmethyl-agomelatine-d3 | 99.69% | 7-Desmethyl-agomelatine-d3 is a deuterium labeled 7-Desmethyl-agomelatine. 7-Desmethyl-agomelatine is a metabolite of Agomelatine. | ||||||||||||||||||||
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References
- [1]. Millan MJ, et al. The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther. 2003 Sep;306(3):954-64. [Content Brief]
- [2]. Li M, et al. Development and validation a LC-MS/MS method for the simultaneous determination of agomelatine and its metabolites, 7-desmethyl-agomelatine and 3-hydroxy-agomelatine in human plasma: Application to a bioequivalence study. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 15;1003:60-6. [Content Brief]
