152317-89-0
152317-89-0
Chemical Structure
Alniditan
Synonym(s): Alnitidan
- CAS No.: 152317-89-0
- Formula:C17H26N4O
- Molecular Weight:302.41
IUPAC Name: (R)-N1-(chroman-2-ylmethyl)-N3-(1,4,5,6-tetrahydropyrimidin-2-yl)propane-1,3-diamine
InChIKey: QVSXOXCYXPQXMF-OAHLLOKOSA-N
SMILES: C1(NCCCNC[C@H]2CCC3=CC=CC=C3O2)=NCCCN1
Biological Activity: Alniditan (Alnitidan) is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK293 cells, respectively. Alniditan has migraine-preventive effects[1][2].
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Alniditan | Alniditan (Alnitidan) is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK293 cells, respectively. Alniditan has migraine-preventive effects. | |||||||||||||||||||||
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References
- [1]. Limmroth V, et al. Effects of alniditan on neurogenic oedema in the rat dura mater and on contraction of rat basilar artery. Eur J Pharmacol. 1999 Oct 8;382(2):103-9. [Content Brief]
- [2]. Lesage AS, et al. Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. Br J Pharmacol. 1998 Apr;123(8):1655-65. [Content Brief]
