152755-31-2
152755-31-2
Chemical Structure
LY 295427
Synonym(s): Agisterol
- CAS No.: 152755-31-2
- Formula:C30H52O
- Molecular Weight:428.73
IUPAC Name: (3R,4S,5S,8S,9S,10R,13R,14S,17R)-4-allyl-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-ol
InChIKey: GSFDFZOSYZNZOA-ROMNCUSUSA-N
SMILES: CC(CCC[C@H]([C@H]1CC[C@]2([C@@]3(CC[C@]4([C@@H]([C@@H](CC[C@@]4([C@]3(CC[C@]12C)[H])C)O)CC=C)[H])[H])[H])C)C
Biological Activity: LY 295427 is a LDL receptor modulator and a hypocholesterolemic agent. LY 295427 derepresses the transcription of the LDLR (LDL Receptor). LY 295427 can be used for hypercholesterolemia research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LY 295427 | 98.0% | LY 295427 is a LDL receptor modulator and a hypocholesterolemic agent. LY 295427 derepresses the transcription of the LDLR (LDL Receptor). LY 295427 can be used for hypercholesterolemia research. | ||||||||||||||||||||
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References
- [1]. Bowling N, et al. LY295427, a novel hypocholesterolemic agent, enhances [3H]25-hydroxycholesterol binding to liver cytosolic proteins. J Lipid Res. 1996 Dec;37(12):2586-98. [Content Brief]
- [2]. George Chang, et al. Low density lipoprotein receptor up-regulation. Expert Opinion on Therapeutic Patents. Volume 9, 1999-Issue 5.
- [3]. Bensch WR, et al. Effects of LY295427, a low-density lipoprotein (LDL) receptor up-regulator, on LDL receptor gene transcription and cholesterol metabolism in normal and hypercholesterolemic hamsters. J Pharmacol Exp Ther. 1999 Apr;289(1):85-92. [Content Brief]
