153050-21-6
153050-21-6
Chemical Structure
Nolpitantium
Synonym(s): SR140333
- CAS No.: 153050-21-6
- Formula:C37H45Cl3N2O2
- Molecular Weight:656.12
IUPAC Name: (S)-1-(2-(3-(3,4-dichlorophenyl)-1-(2-(3-isopropoxyphenyl)acetyl)piperidin-3-yl)ethyl)-4-phenylquinuclidin-1-ium chloride
InChIKey: NQHFSECYQAQZBN-LSYPWIJNSA-M
SMILES: O=C(N1C[C@@](CC[N+]2(CC3)CCC3(C4=CC=CC=C4)CC2)(C5=CC=C(Cl)C(Cl)=C5)CCC1)CC6=CC=CC(OC(C)C)=C6.[Cl-]
Biological Activity: Nolpitantium (SR140333) is a potent, selective, competitive, non-peptide tachykinin NK1 receptor antagonist. Nolpitantium blocks the activation of rat thalamic neurons after nociceptive stimulation[1].
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Nolpitantium | Nolpitantium (SR140333) is a potent, selective, competitive, non-peptide tachykinin NK1 receptor antagonist. Nolpitantium blocks the activation of rat thalamic neurons after nociceptive stimulation. | |||||||||||||||||||||
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