153072-33-4
153072-33-4
Chemical Structure
BMS 183920
- CAS No.: 153072-33-4
- Formula:C26H19N5O3
- Molecular Weight:449.46
IUPAC Name: 3-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)oxy)-2-cyclopropylquinoline-4-carboxylic acid
InChIKey: UVTFLTXWSSGYFE-UHFFFAOYSA-N
SMILES: O=C(C1=C(OC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)C(C5CC5)=NC6=CC=CC=C16)O
Biological Activity: BMS 183920 is a diacidic and potent angiotensin II receptor antagonist, with a Ki value of 2.9 nM in the rat adrenal cortex binding assay and a KB value of 0.061 nM in the rabbit aorta functional assay. BMS 183920 can be used for research of antihypertensive[1][2].
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BMS 183920 | BMS 183920 is a diacidic and potent angiotensin II receptor antagonist, with a Ki value of 2.9 nM in the rat adrenal cortex binding assay and a KB value of 0.061 nM in the rabbit aorta functional assay. BMS 183920 can be used for research of antihypertensive. | |||||||||||||||||||||
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References
- [1]. Obermeier MT, et al. Prodrugs of BMS-183920: metabolism and permeability considerations. J Pharm Sci. 1996 Aug;85(8):828-33. [Content Brief]
- [2]. Wexler RR, et al. Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. J Med Chem. 1996 Feb 2;39(3):625-56.
