1534060-58-6
1534060-58-6
Chemical Structure
Aurkin A
- CAS No.: 1534060-58-6
- Formula:C16H9BrFNO2
- Molecular Weight:346.15
IUPAC Name: 2-(3-bromophenyl)-8-fluoroquinoline-4-carboxylic acid
InChIKey: AONAJNHHHRKZDU-UHFFFAOYSA-N
SMILES: O=C(C1=C2C=CC=C(F)C2=NC(C3=CC(Br)=CC=C3)=C1)O
Biological Activity: Aurkin A is an allosteric inhibitor for the interaction between Aurora A Kinase (also known also Aurka) and TPX2, through targeting the TPX2 binding sites with Kd of 3.77 μM. Aurkin A can disrupt polyploidy induced by Alisertib (HY-10971) and increase apoptosis of tumor cells. Aurkin A can be used in research on mitosis and cancer[1][2].
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Aurkin A | 98.0% | Aurkin A is an allosteric inhibitor for the interaction between Aurora A Kinase (also known also Aurka) and TPX2, through targeting the TPX2 binding sites with Kd of 3.77 μM. Aurkin A can disrupt polyploidy induced by Alisertib (HY-10971) and increase apoptosis of tumor cells. Aurkin A can be used in research on mitosis and cancer. | ||||||||||||||||||||
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References
- [1]. Janeček M, et al., Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2. Sci Rep. 2016 Jun 24;6:28528. [Content Brief]
- [2]. Conway PJ, et al. Aurkin-A, a TPX2-Aurora A small molecule inhibitor disrupts Alisertib-induced polyploidy in aggressive diffuse large B cell lymphoma. Neoplasia. 2024 Sep;55:101014. [Content Brief]
