153415-44-2
Chemical Structure
LEK 8804
- CAS No.: 153415-44-2
- Formula:C19H19N3O
- Molecular Weight:305.37
IUPAC Name: (6aR,9R)-7-methyl-N-(prop-2-yn-1-yl)-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
InChIKey: WZTGESDWBWZMSE-CXAGYDPISA-N
SMILES: [H][C@]1(C2)N(C[C@@H](C=C1C3=CC=CC4=C3C2=CN4)C(NCC#C)=O)C
Biological Activity: LEK 8804 is a compound with 5-HT1A receptor agonist and 5-HT2 receptor antagonist properties, and has the activity of modulating related receptor-mediated behavioral responses. LEK 8804 can induce spontaneous tail-flick response in rats in a dose-dependent manner, showing complete 5-HT1A agonist activity, and can inhibit 5-HTP-induced head twitch response in mice, probably through antagonism of 5-HT2 receptors rather than agonism of 5-HT1A receptors.
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LEK 8804 | LEK 8804 is a compound with 5-HT1A receptor agonist and 5-HT2 receptor antagonist properties, and has the activity of modulating related receptor-mediated behavioral responses. LEK 8804 can induce spontaneous tail-flick response in rats in a dose-dependent manner, showing complete 5-HT1A agonist activity, and can inhibit 5-HTP-induced head twitch response in mice, probably through antagonism of 5-HT2 receptors rather than agonism of 5-HT1A receptors. | |||||||||||||||||||||
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