153624-15-8
153624-15-8
Chemical Structure
BMS-187308
- CAS No.: 153624-15-8
- Formula:C21H25N3O3S
- Molecular Weight:399.51
IUPAC Name: 2'-amino-N-(3,4-dimethylisoxazol-5-yl)-4'-isobutyl-[1,1'-biphenyl]-2-sulfonamide
InChIKey: OZDIAVKCLFSBME-UHFFFAOYSA-N
SMILES: O=S(C1=CC=CC=C1C2=CC=C(CC(C)C)C=C2N)(NC3=C(C)C(C)=NO3)=O
Biological Activity: BMS-187308 is an orally active endothelin-A (ETA) antagonist, with Kis of 4.7 nM for ETA and 1.7 μM for ETB. BMS-187308 inhibits the pressor response to ET-1 (ED25: 1.2 µmol/kg; iv). BMS-187308 is a suitable tool for investigating the role of endothelin[1].
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BMS-187308 | BMS-187308 is an orally active endothelin-A (ETA) antagonist, with Kis of 4.7 nM for ETA and 1.7 μM for ETB. BMS-187308 inhibits the pressor response to ET-1 (ED25: 1.2 µmol/kg; iv). BMS-187308 is a suitable tool for investigating the role of endothelin. | |||||||||||||||||||||
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References
- [1]. Murugesan N, et al. Biphenylsulfonamide endothelin antagonists: structure-activity relationships of a series of mono- and disubstituted analogues and pharmacology of the orally active endothelin antagonist 2'-amino-N- (3,4-dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)[1, 1'-biphenyl]-2-sulfonamide (BMS-187308). J Med Chem. 1998 Dec 17;41(26):5198-218. [Content Brief]
