153633-01-3
Chemical Structure
SC-53228
- CAS No.: 153633-01-3
- Formula:C31H41NO7
- Molecular Weight:539.66
IUPAC Name: (S)-3-(7-(3-(2-(cyclopropylmethyl)-3-methoxy-4-(methylcarbamoyl)phenoxy)propoxy)-8-propylchroman-2-yl)propanoic acid
InChIKey: YWYUQSGYKDEAMJ-QFIPXVFZSA-N
SMILES: CCCC1=C2C(CC[C@H](O2)CCC(O)=O)=CC=C1OCCCOC3=C(C(OC)=C(C=C3)C(NC)=O)CC4CC4
Biological Activity: SC-53228 is an orally active human leukotriene B4 receptor (LTB4 receptor) antagonist. SC-53228 exerts its anti-inflammatory effect by specifically blocking the LTB4 receptor and inhibiting neutrophil infiltration. SC-53228 has demonstrated significant efficacy and good safety in various inflammatory models. SC-53228 can be used for a variety of inflammatory diseases, such as psoriasis and ulcerative colitis[1][2].
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SC-53228 | SC-53228 is an orally active human leukotriene B4 receptor (LTB4 receptor) antagonist. SC-53228 exerts its anti-inflammatory effect by specifically blocking the LTB4 receptor and inhibiting neutrophil infiltration. SC-53228 has demonstrated significant efficacy and good safety in various inflammatory models. SC-53228 can be used for a variety of inflammatory diseases, such as psoriasis and ulcerative colitis. | |||||||||||||||||||||
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References
- [1]. Fretland DJ, et al. Dermal inflammation in primates, mice, and guinea pigs: attenuation by second-generation leukotriene B4 receptor antagonist, SC-53228. Inflammation. 1995 Jun;19(3):333-46. [Content Brief]
- [2]. Fretland D, et al. Oral efficacy of a leukotriene B4 receptor antagonist in colitic cotton-top tamarins. Gut. 1995 Nov;37(5):702-7. [Content Brief]
