1539296-45-1
1539296-45-1
Chemical Structure
PF470
Synonym(s): PF-06297470
- CAS No.: 1539296-45-1
- Formula:C18H16N6O
- Molecular Weight:332.36
IUPAC Name: 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo[3,4-b]pyrazine
InChIKey: RDLSKDOSNKLEAQ-UHFFFAOYSA-N
SMILES: CC1=C(C2=NN(C)C3=NC(OCC4=NC=CC=C4)=CN=C32)C=NC=C1
Biological Activity: PF470 (PF-06297470) is a negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5) with significant efficacy in Parkinson's disease models, but clinical development was halted due to potential issues found in toxicology studies.
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PF470 | PF470 (PF-06297470) is a negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5) with significant efficacy in Parkinson's disease models, but clinical development was halted due to potential issues found in toxicology studies. | |||||||||||||||||||||
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