154116-31-1
Chemical Structure
CGS 26303
- CAS No.: 154116-31-1
- Formula:C16H18N5O3P
- Molecular Weight:359.32
IUPAC Name: (S)-(((2-([1,1'-biphenyl]-4-yl)-1-(1H-tetrazol-5-yl)ethyl)amino)methyl)phosphonic acid
InChIKey: UUMKQZVEZSXWBY-HNNXBMFYSA-N
SMILES: O=P(O)(O)CN[C@H](C1=NN=NN1)CC2=CC=C(C3=CC=CC=C3)C=C2
Biological Activity: CGS 26303 is an endothelin-converting enzyme (ECE) inhibitor. CGS 26303 increases the expression of endothelin-converting enzyme-1 in endothelial cells. CGS 26303 attenuates cerebral vasospasm in a rabbit subarachnoid hemorrhage model. CGS 26303 improves birth survival and alleviates pulmonary hypoplasia in newborn rats in a rat model of congenital diaphragmatic hernia. CGS 26303 can be used for research on cardiovascular and cerebrovascular diseases and congenital diaphragmatic hernia[1][2][3].
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CGS 26303 | CGS 26303 is an endothelin-converting enzyme (ECE) inhibitor. CGS 26303 increases the expression of endothelin-converting enzyme-1 in endothelial cells. CGS 26303 attenuates cerebral vasospasm in a rabbit subarachnoid hemorrhage model. CGS 26303 improves birth survival and alleviates pulmonary hypoplasia in newborn rats in a rat model of congenital diaphragmatic hernia. CGS 26303 can be used for research on cardiovascular and cerebrovascular diseases and congenital diaphragmatic hernia. | |||||||||||||||||||||
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References
- [1]. Raoch V, et alS. The peptidase inhibitor CGS-26303 increases endothelin converting enzyme-1 expression in endothelial cells through accumulation of big endothelin-1. Br J Pharmacol. 2007 Oct;152(3):313-22. [Content Brief]
- [2]. Kwan AL, et al. Continuous intravenous infusion of CGS 26303, an endothelin-converting enzyme inhibitor, prevents and reverses cerebral vasospasm after experimental subarachnoid hemorrhage. Neurosurgery. 2001 Aug;49(2):422-7; discussion 427-9. d [Content Brief]
- [3]. Kavanagh M, et al. Effect of CGS 26303, an endothelin-converting enzyme-neutral endopeptidase inhibitor, on nitrofen-induced congenital diaphragmatic hernia in the rat. J Pediatr Surg. 2000 May;35(5):780-4. [Content Brief]
