1542132-88-6
1542132-88-6
Chemical Structure
Vilagletistat
Synonym(s): ZED-1227
- CAS No.: 1542132-88-6
- Formula:C26H36N6O6
- Molecular Weight:528.60
IUPAC Name: methyl (S,E)-7-((1-(2-((2-ethylbutyl)amino)-2-oxoethyl)-2-oxo-1,2-dihydropyridin-3-yl)amino)-6-(1-methyl-1H-imidazole-5-carboxamido)-7-oxohept-2-enoate
InChIKey: VHGWUSABWIEXKQ-BEBFYNPSSA-N
SMILES: O=C(OC)/C=C/CC[C@H](NC(C1=CN=CN1C)=O)C(NC2=CC=CN(CC(NCC(CC)CC)=O)C2=O)=O
Biological Activity: ZED-1227 is a specific and orally active transglutaminase 2 (TG2) inhibitor, with an IC50 of 45 nM. ZED-1227 can block inflammation-induced TG2 expression and activity. ZED-1227 can be used for the research of celiac disease (CeD)[1][2].
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Vilagletistat | 99.82% | ZED-1227 is a specific and orally active transglutaminase 2 (TG2) inhibitor, with an IC50 of 45 nM. ZED-1227 can block inflammation-induced TG2 expression and activity. ZED-1227 can be used for the research of celiac disease (CeD). | ||||||||||||||||||||
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