1544-68-9
Chemical Structure
4-Fluorophenyl isothiocyanate
- CAS No.: 1544-68-9
- Formula:C7H4FNS
- Molecular Weight:153.17
IUPAC Name: 1-fluoro-4-isothiocyanatobenzene
InChIKey: NFIUJHJMCQQYDL-UHFFFAOYSA-N
SMILES: FC1=CC=C(N=C=S)C=C1
Biological Activity: 4-Fluorophenyl isothiocyanate is an aryl isothiocyanate reagent and synthetic building block. 4-Fluorophenyl isothiocyanate is used to prepare quinazolinone derivatives, (S)-naproxen-derived 1,2,4-triazoles, isoniazid-derived thiosemicarbazones, isatin-β-thiosemicarbazones, thioureas, thiazolidinones, thiazolines, triazoles, and thiadiazoles. 4-Fluorophenyl isothiocyanate reacts with hydrazine to form a dimer of two thiocyanate groups linked by hydrazine, and the formation of this dimer can be avoided by reacting tert-butyl carbazate with the isothiocyanate[1][2][3][4][5][6][7].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
4-Fluorophenyl isothiocyanate | 4-Fluorophenyl isothiocyanate is an aryl isothiocyanate reagent and synthetic building block. 4-Fluorophenyl isothiocyanate is used to prepare quinazolinone derivatives, (S)-naproxen-derived 1,2,4-triazoles, isoniazid-derived thiosemicarbazones, isatin-β-thiosemicarbazones, thioureas, thiazolidinones, thiazolines, triazoles, and thiadiazoles. 4-Fluorophenyl isothiocyanate reacts with hydrazine to form a dimer of two thiocyanate groups linked by hydrazine, and the formation of this dimer can be avoided by reacting tert-butyl carbazate with the isothiocyanate. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Geesi MH. New quinazoline-N-4-fluorophenyl derivatives as potential anticancer agents: Discovery of a promising dual EGFR/VEGFR-2 inhibitor. Journal of King Saud University–Science. 2024 Dec 1;36.
- [2]. Han M İ, et al. Synthesis and characterization of 1, 2, 4-triazole containing hydrazide-hydrazones derived from (S)-Naproxen as anticancer agents[J]. Journal of Research in Pharmacy, 2018, 22(4): 559-569.
- [3]. Rizvi F, et al. Studies on Isoniazid Derivatives through a Medicinal Chemistry Approach for the Identification of New Inhibitors of Urease and Inflammatory Markers. Sci Rep. 2019 May 1;9(1):6738.
- [4]. Makki M, et al. New route to synthesize fluorine substituted lamotrigine drug analogues as an anti-inflammatory agent[J]. Current Organic Synthesis, 2018, 15(1): 116-125.
- [5]. Szakács G, et al. Targeting the Achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance. Chem Rev. 2014 Jun 11;114(11):5753-74.
- [6]. Yolal M, et al. Synthesis of eperezolid-like molecules and evaluation of their antimicrobial activities. Bioorg Khim. 2012 Sep-Oct;38(5):610-20.
- [7]. Krajsovszky G, et al. Synthesis of Novel Anion Recognition Molecules as Quinazoline Precursors. International journal of molecular sciences. 2025 Dec 12;26(24):11975.
