1544739-76-5
Chemical Structure
(5aS,6R,6aR)-MK-8666
- CAS No.: 1544739-76-5
- Formula:C29H31NO6S
- Molecular Weight:521.62
InChIKey: CODQKEMYZZKQAE-MXSCXNJPSA-N
SMILES: OC([C@H]1[C@@]2([H])[C@]1([H])CC3=CC(OCC4=CC(C5=C(C=C(C=C5C)OCCCS(C)(=O)=O)C)=CC=C4)=NC=C32)=O
Biological Activity: (5aS,6R,6aR)-MK-8666 is a selective GPR40 agonist with activity in promoting fatty acid-induced insulin secretion in pancreatic β cells and intestinal enteroendocrine cells. (5aS,6R,6aR)-MK-8666 has been studied for the inhibition of type 2 diabetes and has shown significant blood glucose lowering effects. Although (5aS,6R,6aR)-MK-8666 is considered to have potential inhibitory advantages, its development was stopped in Phase I clinical trials due to liver safety issues[1].
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(5aS,6R,6aR)-MK-8666 | (5aS,6R,6aR)-MK-8666 is a selective GPR40 agonist with activity in promoting fatty acid-induced insulin secretion in pancreatic β cells and intestinal enteroendocrine cells. (5aS,6R,6aR)-MK-8666 has been studied for the inhibition of type 2 diabetes and has shown significant blood glucose lowering effects. Although (5aS,6R,6aR)-MK-8666 is considered to have potential inhibitory advantages, its development was stopped in Phase I clinical trials due to liver safety issues. | |||||||||||||||||||||
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